2-Pyridineethanamine → S9947

HRID 2109556Notes

Reaction equation

HRID 2109556 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[C:20]([C:25](O)=[O:26])=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[CH2:34][CH2:35][NH2:36]>CCCCCCC.CC(=O)OCC>[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[CH2:34][CH2:35][NH:36][C:25]([C:20]1[C:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[CH2:12][NH:11][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:26]

Participants

4

Reactant 2

HCID 759192-PyridineethanamineHCID 109153932'-(Benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid

Product 1

HCID 656730S9947

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

From 0.28 mmol of 2′-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid (precursor 6) and 2-(2-pyridyl)ethylamine, according to ,the general working procedure and subsequent purification by flash chromatography 85 mg of 2′-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide were obtained; m.p. 140° C. (heptane/EA); MS (ES+): m/e=466 (M+1).

Workup

  1. customgeneral working procedure and subsequent purification by flash chromatography 85 mg of 2′-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide
  2. customwere obtained

Sources & evidence

ORD record
ord-9790f934e0a54cfdae806ea339ceee0b
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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