4-Piperidinol, 1-methyl- → HCID 10299030, compound

HRID 2109613Notes

Reaction equation

HRID 2109613 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([C:13]2[C:14]([NH:19][C:20]3[CH:28]=[C:27]4[C:23]([CH:24]=[N:25][NH:26]4)=[CH:22][CH:21]=3)=[N:15][CH:16]=[CH:17][CH:18]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O[CH:30]1[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]1>>[NH:26]1[C:27]2[C:23](=[CH:22][CH:21]=[C:20]([NH:19][C:14]3[C:13]([C:11]([NH:10][C:4]4[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([O:1][CH:30]5[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]5)[CH:3]=4)=[O:12])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:28]=2)[CH:24]=[N:25]1

Participants

3

Reactant 2

HCID 660484-Piperidinol, 1-methyl-HCID 10177466HCID 10177466, compound

Product 1

HCID 10299030HCID 10299030, compound

Procedure

The title compound was prepared from N-(3-hydroxy-4-methoxyphenyl) [2-(1H-indazol-6-ylamino) (3-pyridyl)]-carboxamide (Example 36) by a method similar to that described in Example 34 using 4-hydroxy-N-methylpiperidine. MS (ES+): 473 (M+H)+; (ES−): 471 (M−H). Calc'd. for C26H28N6O3−472.2.

Sources & evidence

ORD record
ord-e6ec826babe543dcb9eb468742eb3c15
Source dataset
uspto-grants-2009_04
Patent number
US07514564B2

Reaction notes

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