反应详情

N-(4-(Chloromethyl)thiazol-2-yl)acetamide (2.0 g, 10 mmol) in 20 mL THF was added in portions to dimethylamine (4.7 g, 105 mmol). After addition, the mixture was stirred for an additional 30 minutes. The solvent was removed under reduced pressure. 200 mL distilled water was then added to the resulting residue, and the mixture was extracted with EtOAc. The EtOAc solution was washed with brine solution and dried over sodium sulfate. After removing the solvent, an off-white solid was obtained as the crude product (1.3 g, yield=80%). LCMS (API-ES) m/z (%) 200.1 (100%, M++H). 1H NMR (400 MHz, CDCl3) δ ppm 2.24 (s, 3H) 2.26 (s, 6H) 3.43 (s, 2H) 6.73 (s, 1H).

1. additionAfter addition
2. customThe solvent was removed under reduced pressure
3. distillation200 mL distilled water
4. additionwas then added to the resulting residue
5. extractionthe mixture was extracted with EtOAc
6. washThe EtOAc solution was washed with brine solution
7. dry with materialdried over sodium sulfate
8. customAfter removing the solvent