HCID 57634629, compound → HCID 57634649, compound

HRID 2109828Notes

Reaction equation

HRID 2109828 reaction equation
[C:1]([N:4]1[CH:9]=[CH:8][N:7]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:6](=[O:18])[CH2:5]1)(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:6](=[O:18])[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 57634629HCID 57634629, compound

Product 1

HCID 57634649HCID 57634649, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-acetyl-1-(4-fluorobenzyl)-3,4-dihydropyrazin-2(1H)-one (141 g, 0.57 mol) and 5% Pd/C (10.4 g) in ethanol (500 mL) was stirred under an atmosphere of hydrogen (1 atm) at room temperature overnight. The product mixture was filtered through a pad of Celite, and concentrated under vacuum to provide the title compound. Residual ethanol was removed by co-evaporation with toluene (3×) under vacuum. The resultant oil solidify on standing and was used in the next step without further purification.

Workup

  1. filtrationThe product mixture was filtered through a pad of Celite
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-4b3881d345864669a2834e0cad872be6
Source dataset
uspto-grants-2009_04
Patent number
US07517532B2

Reaction notes

Loading…