HCID 57634629, compound → HCID 57634649, compound

Participants

Reaction Steps

A mixture of 4-acetyl-1-(4-fluorobenzyl)-3,4-dihydropyrazin-2(1H)-one (141 g, 0.57 mol) and 5% Pd/C (10.4 g) in ethanol (500 mL) was stirred under an atmosphere of hydrogen (1 atm) at room temperature overnight. The product mixture was filtered through a pad of Celite, and concentrated under vacuum to provide the title compound. Residual ethanol was removed by co-evaporation with toluene (3×) under vacuum. The resultant oil solidify on standing and was used in the next step without further purification.

Provenance & Evidence