反应详情

A mixture of N-[(tert-butoxy)carbonyl]-N-(2-oxopropyl)glycine (0.66 g, 2.87 mmol), 4-fluorobenzylamine (0.23 g, 1.87 mmol) in dichloroethane (14 mL) was stirred at room temperature for one hour. Sodium triacetoxyborohydride (0.79 g, 3.73 mmol) was added and the reaction mixture stirred at room temperature overnight. The resultant mixture was concentrated under vacuum. The residue was dissolved in DMF (12 mL), treated with EDC (0.55 g), and stirred at room temperature overnight. The resultant mixture was concentrated under vacuum. The residue was partitioned between ethyl acetate and dilute aqueous HCl. The organic extract was washed with brine (to pH 7), dried over anhydrous magnesium sulfate, filtered, and concentrated to provide the title compound.

1. stirringthe reaction mixture stirred at room temperature overnight
2. concentrationThe resultant mixture was concentrated under vacuum
3. dissolutionThe residue was dissolved in DMF (12 mL)
4. additiontreated with EDC (0.55 g)
5. stirringstirred at room temperature overnight
6. concentrationThe resultant mixture was concentrated under vacuum
7. customThe residue was partitioned between ethyl acetate and dilute aqueous HCl
8. extractionThe organic extract
9. washwas washed with brine (to pH 7)
10. dry with materialdried over anhydrous magnesium sulfate
11. filtrationfiltered
12. concentrationconcentrated