Ethanolamine → 2-((Triphenylmethyl)amino)ethanol

HRID 2109877Notes

Reaction equation

HRID 2109877 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[C:5](Cl)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N1C=CC=CC=1>O>[C:5]([NH:4][CH2:3][CH2:1][OH:2])([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 700EthanolamineHCID 1049PyridineHCID 6456Trityl chloride

Product 1

HCID 31256082-((Triphenylmethyl)amino)ethanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of ethanolamine, trityl chloride and pyridine was refluxed for 15 h. Water was added slowly to the cooled reaction and the precipitate collected by filtration. The crude product recrystallized from a 1:1 mixture of ethanol and water.

Workup

  1. temperaturewas refluxed for 15 h
  2. filtrationthe precipitate collected by filtration
  3. customThe crude product recrystallized from a 1:1 mixture of ethanol and water

Sources & evidence

ORD record
ord-72f277c209354929abb4a20710e14cdc
Source dataset
uspto-grants-2009_04
Patent number
US07517858B1

Reaction notes

Loading…