Piperazine → HCID 11221930, compound

HRID 2109880Notes

Reaction equation

HRID 2109880 reaction equation
[O:1]1[C:6]2=[CH:7][C:8]3[NH:14][C:13](=O)[C:12]4[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=4[S:10][C:9]=3[CH:20]=[C:5]2[O:4][CH2:3][CH2:2]1.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[N:21]1([C:13]2[C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[S:10][C:9]3[CH:20]=[C:5]4[O:4][CH2:3][CH2:2][O:1][C:6]4=[CH:7][C:8]=3[N:14]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 2342150HCID 2342150, compound

Product 1

HCID 11221930HCID 11221930, compoundYield 5.4%

Procedure

2,3-Dihydro-1,4-benzodioxino[6,7-b][1,4]benzothiazepin-11(12H)-one (29 mg, 0.1 mmol) and piperazine (43 mg, 0.5 mmol) were reacted according to GP4 to give 1.9 mg of the title compound (160FE17B). MS (ESI) 354 (MH+). Purity for MH+ (UV/MS) 99/95.

Sources & evidence

ORD record
ord-f4813071a53342789004223a61a2b2f2
Source dataset
uspto-grants-2009_04
Patent number
US07517871B2

Reaction notes

Loading…