Piperazine → 3-Chloro-6-piperazin-1-yl-11H-dibenzo[b,e]azepine

HRID 2109894Notes

Reaction equation

HRID 2109894 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=O)[NH:7][C:6]=2[CH:17]=1.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[N:7][C:6]=2[CH:17]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 574854323-Chloro-5,11-dihydro-dibenzo[b,e]azepin-6-one

Product 1

HCID 112899173-Chloro-6-piperazin-1-yl-11H-dibenzo[b,e]azepine

Procedure

3-Chloro-5,11-dihydro-dibenzo[b,e]azepin-6-one (189JO59) (25 mg, 0.1 mmol) and piperazine were reacted according to GP4 to give 2.2 mg of the title compound (189JO60). MS (ESI) 312 (MH+). Purity for MH+ (UV/MS) 100/100.

Sources & evidence

ORD record
ord-6335054f515a4eea87f8303ed74a19c6
Source dataset
uspto-grants-2009_04
Patent number
US07517871B2

Reaction notes

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