1,1-Dimethylethyl 2-(4-piperidinyl)hydrazinecarboxylate → HCID 136029241, compound

HRID 2109906Notes

Reaction equation

HRID 2109906 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](SC)=[N:7][C:6]=2[CH:18]=1.C(OC(N[NH:27][CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N:31]3[CH2:32][CH2:33][CH:28]([NH2:27])[CH2:29][CH2:30]3)=[N:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 671592811,1-Dimethylethyl 2-(4-piperidinyl)hydrazinecarboxylateHCID 136056013HCID 136056013, compound

Product 1

HCID 136029241HCID 136029241, compoundYield 18.1%

Procedure

8-Chloro-11-methylsulfanyl-5H-dibenzo[b,e][1,4]diazepine (166JO50) (50 mg, 0.11 mmol) and 4-(tert-butoxycarbonylamino)aminopiperidine (39 mg, 0.2 mmol) were reacted according to GP8 to give 6.5 mg of the title compound (166JO55). MS (ESI) 327 (MH+). Purity for MH+ (UV/MS) 100/99.

Sources & evidence

ORD record
ord-69b00fb721794bd3ab128ba8d1840244
Source dataset
uspto-grants-2009_04
Patent number
US07517871B2

Reaction notes

Loading…