HCID 68631976, compound → HCID 178477857, compound

HRID 2109908Notes

Reaction equation

HRID 2109908 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](SC)=[N:7][C:6]=2[CH:18]=1.[NH2:19][CH:20]1[CH2:24][CH2:23][N:22](NC(OC(C)(C)C)=O)[CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([NH:19][CH:20]3[CH2:24][CH2:23][NH:22][CH2:21]3)=[N:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 68631976HCID 68631976, compoundHCID 136056013HCID 136056013, compound

Product 1

HCID 178477857HCID 178477857, compoundYield 11.2%

Procedure

8-Chloro-11-methylsulfanyl-5H-dibenzo[b,e][1,4]diazepine (166JO50) (100 mg, 0.22 mmol) and 3-amino-1-N-(tert-butoxycarbonylamino)pyrrolidine (73 mg, 0.4 mmol) were reacted according to GP8 to give 7.7 mg of the title compound (166JO74). MS (ESI) 313 (MH+). Purity for MH+ (UV/MS) 100/90.

Sources & evidence

ORD record
ord-4d400198c8cb4dc1a87fb44599eeb851
Source dataset
uspto-grants-2009_04
Patent number
US07517871B2

Reaction notes

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