8,5-Dichloro-5H-dibenzo[b,e][1,4]diazepine → HCID 136029246, compound

HRID 2109911Notes

Reaction equation

HRID 2109911 reaction equation
[Cl-].[F:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Zn+])=[CH:5][CH:4]=1.[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[N:21](Cl)[C:20]3[CH:23]=[CH:24][CH:25]=[CH:26][C:19]=3C=[N:17][C:16]=2[CH:27]=1>>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[NH:21][C:20]3[CH:23]=[CH:24][CH:25]=[CH:26][C:19]=3[C:7]([C:6]3[CH:9]=[CH:10][C:3]([F:2])=[CH:4][CH:5]=3)=[N:17][C:16]=2[CH:27]=1

Participants

3

Reactant 2

HCID 574854318,5-Dichloro-5H-dibenzo[b,e][1,4]diazepineHCID 178505764HCID 178505764, compound

Product 1

HCID 136029246HCID 136029246, compoundYield 71.3%

Procedure

4-Fluorobenylzinc chloride (0.5 ml, 0.5 M in THF, 0.4 mmol) and 8,5-dichloro-5H-dibenzo[b,e][1,4]diazepine (160FE64) (26 mg, 0.1 mmol) were reacted according GP10 to give 23 mg of the title compound (160FE70). MS (ESI) 323 (MH+). Purity for MH+ (UV/MS) 98/100.

Sources & evidence

ORD record
ord-4adefb58fdcd43b990ffe78893994ee0
Source dataset
uspto-grants-2009_04
Patent number
US07517871B2

Reaction notes

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