反应详情

1.78 g (4.63 mmol) of methyl 4-{[(tert-butoxycarbonyl)-(2-hydroxyphenethyl)-amino]methyl}benzoate from Ex.V.2, 1.05 g (4.63 mmol) of 5-phenyl-1-bromopentane and 0.77 g (5.55 mmol) of potassium carbonate in 15 ml of acetonitrile are heated at reflux for 18 hours. The reaction mixture is poured into water, extracted with ethyl acetate and dried over magnesium sulphate and the solvent is distilled off under reduced pressure. A solid is obtained which is reacted further without purification.

1. temperatureat reflux for 18 hours
2. extractionextracted with ethyl acetate
3. dry with materialdried over magnesium sulphate
4. distillationthe solvent is distilled off under reduced pressure
5. customA solid is obtained which
6. customis reacted further without purification