Methyl 4-Formylbenzoate → Methyl 4-({[2-(5-fluoro-2-methoxyphenyl)ethyl]imino}methyl)benzoate

HRID 2110248Notes

Reaction equation

HRID 2110248 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH2:8][CH2:9][NH2:10])[CH:7]=1.[CH:13]([C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=1)=O>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH2:8][CH2:9][N:10]=[CH:13][C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 15294Methyl 4-FormylbenzoateHCID 220150102-(5-Fluoro-2-methoxyphenyl)ethan-1-amine

Product 1

HCID 22014991Methyl 4-({[2-(5-fluoro-2-methoxyphenyl)ethyl]imino}methyl)benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

9.00 g (53 mmol) of 2-(5-fluoro-2-methoxyphenyl)ethylamine and 8.73 g (53 mmol) of methyl 4-formylbenzoate are dissolved in 450 ml of ethanol, the mixture is heated at reflux for 2 hours and the solvents are then evaporated under reduced pressure.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 2 hours
  3. customthe solvents are then evaporated under reduced pressure

Sources & evidence

ORD record
ord-145d0464a6b543b391cefd5781779600
Source dataset
uspto-grants-2009_04
Patent number
US07517896B2

Reaction notes

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