Hydrazine hydrate (1:1) → HCID 86760856, compound

Participants

Reaction Steps

A solution of 1.49 g of tert-butyl(4′-cyano-3,2′,3′-trifluorobiphenyl-4-yl)carbamate in 40 mL of ethanol is admixed with 2.14 g of hydrazine hydrate and then the mixture is heated at reflux for 18 h. The reaction medium is concentrated to dryness under reduced pressure, the residue is taken up in distilled water and the solid thus obtained is isolated by filtration and then dried. This gives 1.5 g of tert-butyl[4-(3-amino-7-fluoro-1H-indazol-6-yl)-2-fluorophenyl]carbamate in the form of a white solid, whose characteristics are as follows:

Provenance & Evidence