Hydrazine hydrate (1:1) → HCID 86760856, compound

HRID 2110279Notes

Reaction equation

HRID 2110279 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[C:16](F)[C:15]=2[F:23])=[CH:10][C:9]=1[F:24])([CH3:4])([CH3:3])[CH3:2].O.[NH2:27][NH2:28]>C(O)C>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15]([F:23])=[C:16]3[C:17]([C:20]([NH2:21])=[N:27][NH:28]3)=[CH:18][CH:19]=2)=[CH:10][C:9]=1[F:24])([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 131727401HCID 131727401, compound

Product 1

HCID 86760856HCID 86760856, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1.49 g of tert-butyl(4′-cyano-3,2′,3′-trifluorobiphenyl-4-yl)carbamate in 40 mL of ethanol is admixed with 2.14 g of hydrazine hydrate and then the mixture is heated at reflux for 18 h. The reaction medium is concentrated to dryness under reduced pressure, the residue is taken up in distilled water and the solid thus obtained is isolated by filtration and then dried. This gives 1.5 g of tert-butyl[4-(3-amino-7-fluoro-1H-indazol-6-yl)-2-fluorophenyl]carbamate in the form of a white solid, whose characteristics are as follows:

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 18 h
  3. concentrationThe reaction medium is concentrated to dryness under reduced pressure
  4. customthe solid thus obtained
  5. customis isolated by filtration
  6. customdried

Sources & evidence

ORD record
ord-2ba33c27f196428d86c576e777967510
Source dataset
uspto-grants-2009_04
Patent number
US07517902B2

Reaction notes

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