Morpholine → HCID 68905004, compound

HRID 2110328Notes

Reaction equation

HRID 2110328 reaction equation
[ClH:1].[N:2]1([CH:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:12]([OH:21])[CH2:13][N:14]2[CH2:19][CH2:18]N(C)[CH2:16][CH2:15]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.Cl.Cl.N1(C(C2C=CC=CC=2)C([OH:49])CN2CCN(C)CC2)C2C(=CC=CC=2)C=C1.N1CCOCC1>>[ClH:1].[N:2]1([CH:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:12]([OH:21])[CH2:13][N:14]2[CH2:19][CH2:18][O:49][CH2:16][CH2:15]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 68904473HCID 68904473, compoundHCID 68906810HCID 68906810, compound

Product 1

HCID 68905004HCID 68905004, compound

Procedure

In an analogous manner to EXAMPLE 1, step 3 (1RS,2SR)-1-(1H-indol-1-yl)-3-(4-methylpiperazin-1-yl)-1-phenylpropan-2-ol hydrochloride was prepared from (2RS,3RS)-toluene-4-sulfonic acid 2-hydroxy-3-indol-1-yl-3-phenyl-propyl ester (EXAMPLE 1, step 3) and morpholine. MS (ESI) m/z 337 ([M+H]+); HRMS: calcd for C21H24N2O2+H+, 337.19105; found (ESI, [M+H]+), 337.1909.

Sources & evidence

ORD record
ord-a9e23c92f0b940b184ee2f0f78472622
Source dataset
uspto-grants-2009_04
Patent number
US07517899B2

Reaction notes

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