Methylamine → HCID 68907656, compound

HRID 2110349Notes

Reaction equation

HRID 2110349 reaction equation
[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([C@@:9]([N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[CH:28]=3)[CH:23]=[CH:22]2)(C2C=CC=CC=2)[C@H:10]([OH:14])[CH2:11][NH:12][CH3:13])[CH:6]=[CH:7][CH:8]=1.COC1C=C2C(C=CN2[C@@H](C2C=CC=C(F)C=2)[C@H](O)COS(C2C=CC(C)=CC=2)(=O)=O)=CC=1.CN>>[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([C@H:9]([N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[CH:28]=3)[CH:23]=[CH:22]2)[C@H:10]([OH:14])[CH2:11][NH:12][CH3:13])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 68903088HCID 68903088, compoundHCID 87618488HCID 87618488, compound

Product 1

HCID 68907656HCID 68907656, compound

Procedure

In an analogous manner to EXAMPLE 5, (1S,2R)-1-(3-fluorophenyl)-1-(6-methoxy-1H-indol-1-yl)-3-(methylamino)-1-phenylpropan-2-ol hydrochloride was prepared from (2S,3S)-toluene-4-sulfonic acid 3-(6-methoxy-indol-1-yl)-2-hydroxy-3-(3-fluorophenyl)-propyl ester and methylamine as a white solid. MS (ES) m/z 329.2; HRMS: calcd for C19H21FN2O2+H+, 329.16598; found (ESI, [M+H]+), 329.1663.

Sources & evidence

ORD record
ord-831e036fd9fd4326b667776391c59db1
Source dataset
uspto-grants-2009_04
Patent number
US07517899B2

Reaction notes

Loading…