HCID 21875453, compound → 5-Amino-3-methoxypyridine-2-carbonitrile

HRID 2110472Notes

Reaction equation

HRID 2110472 reaction equation
[C:1]([C:3]1[C:8]([O:9][CH3:10])=[CH:7][C:6]([N+:11]([O-])=O)=[CH:5][N:4]=1)#[N:2]>CCOC(C)=O.CC(O)=O.[Fe]>[NH2:11][C:6]1[CH:7]=[C:8]([O:9][CH3:10])[C:3]([C:1]#[N:2])=[N:4][CH:5]=1

Participants

4

Reactant 1

HCID 21875453HCID 21875453, compound

Product 1

HCID 218753365-Amino-3-methoxypyridine-2-carbonitrileYield 97%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 22609514Ethyl acetate acetateSolvent

Conditions

Temperature
65 °C

Procedure

2-Cyano-3-methoxy-5-nitropyridine (1.0 g, 5.6 mmol) was dissolved in 1:1 EtOAc/AcOH (10 mL) and heated to 65° C. Iron powder (1.61 g, 28 mmol, 325 mesh) was added and the mixture stirred for two h. The mixture was filtered though Celite and the filtrate concentrated in vacuo. The residue was partitioned between EtOAc and saturated aqueous sodium bicarbonate. The organic layer was separated, washed with brine, dried (MgSO4), filtered and concentrated. The residue was purified by SiO2 Prep-TLC using CH2Cl2 as the eluent to give the compound 762D (0.805 g, 97%) as an off-white solid. HPLC: 100% at 1.31 min(YMC S5 ODS column) eluting with 10-90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 149.90 [M+H]+.

Workup

  1. filtrationThe mixture was filtered though Celite
  2. concentrationthe filtrate concentrated in vacuo
  3. customThe residue was partitioned between EtOAc and saturated aqueous sodium bicarbonate
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe residue was purified by SiO2 Prep-TLC

Sources & evidence

ORD record
ord-e1a854ecaea64442ae3db4655ae50544
Source dataset
uspto-grants-2009_04
Patent number
US07517904B2

Reaction notes

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