HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Hydroxy-4-(3-methylbutyl)naphthalene-1,3 (2h,4h)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 1-(3-methylbutyl)-2,4-dioxo-1,2,3,4-tetrahydronaphthalene-1-carboxylate | HCID 68839914 | — |
| Product | 4-Hydroxy-4-(3-methylbutyl)naphthalene-1,3 (2h,4h)-dione | HCID 68842241 | 63.2% |
Reaction Steps
A solution of Example 2C (1 g, 3.47 mmol) in 1 N NaOH (20.8 mL) was stirred at 40° C. for 4 days. The solution was neutralized to pH 7 with 1 N HCl, extracted with ethyl acetate, and the organic layer was concentrated in vacuo. Column chromatography on silica (7% methanol/dichloromethane) afforded the title compound as a white solid (0.54 g, 63.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07517876B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-fe5f5205acf04872bf7b562b322164ad |
| Source note | uspto-grants-2009_04 |