Sodium Hydroxide → HCID 87441538, compound

HRID 2110904Notes

Reaction equation

HRID 2110904 reaction equation
[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:9]([CH2:18][C:19]3[CH:38]=[CH:37][C:22]([CH2:23][O:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[C:27]([F:36])[CH:26]=4)=[CH:21][C:20]=3[O:39][CH:40]([CH3:42])[CH3:41])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].[Cl-].[Ca+2:46].[Cl-]>CO.O>[Ca+2:46].[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:9]([CH2:18][C:19]3[CH:38]=[CH:37][C:22]([CH2:23][O:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][C:33]([O-:35])=[O:34])=[C:27]([F:36])[CH:26]=4)=[CH:21][C:20]=3[O:39][CH:40]([CH3:42])[CH3:41])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:9]([CH2:18][C:19]3[CH:38]=[CH:37][C:22]([CH2:23][O:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][C:33]([O-:35])=[O:34])=[C:27]([F:36])[CH:26]=4)=[CH:21][C:20]=3[O:39][CH:40]([CH3:42])[CH3:41])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 5284359Calcium ChlorideHCID 23159854HCID 23159854, compound

Product 1

HCID 87441538HCID 87441538, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[4-({4-[(3,5-Diphenyl-1H-pyrazol-1-yl)methyl]-3-isopropoxybenzyl)oxy)-2-fluorophenyl]propanoic acid (0.32 g, 0.56 mmol) was dissolved in methanol (3 mL), and 1 N aqueous sodium hydroxide solution (0.56 mL, 0.56 mmol) was added. Then, a solution of calcium chloride (31 mg, 0.28 mmol) in water (1 mL) was added, and the precipitated solid was collected by filtration, washed with water and methanol, and dried to give the title compound (0.27 g, yield 83%) as a colorless powder. MS (ESI+): 565 (M+H, as free form).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with water and methanol
  3. customdried

Sources & evidence

ORD record
ord-c0cb17b5309b417e84659149b4fbb75f
Source dataset
uspto-grants-2009_04
Patent number
US07517910B2

Reaction notes

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