1-Bromo-2-butanone → HCID 68905741, compound

HRID 2110921Notes

Reaction equation

HRID 2110921 reaction equation
[NH2:1][C:2](=[S:13])[CH2:3][CH2:4][NH:5]C(=O)OC(C)(C)C.[Br:14][CH2:15][C:16](=O)[CH2:17][CH3:18]>C(O)C>[BrH:14].[CH2:17]([C:16]1[N:1]=[C:2]([CH2:3][CH2:4][NH2:5])[S:13][CH:15]=1)[CH3:18]

Participants

4

Reactant 2

HCID 131561-Bromo-2-butanoneHCID 2735653tert-Butyl (3-amino-3-sulfanylidenepropyl)carbamate

Product 1

HCID 68905741HCID 68905741, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.00 g (9.50 mmol) tert.butyl N(3-amino-3-thioxopropyl)carbamate and 1.58 g (10.45 mmol) 1-bromo-2-butanone are refluxed in 40 ml of ethanol for 16 hours with stirring. The reaction mixture is evaporated down, the residue is purified by chromatography.

Workup

  1. customThe reaction mixture is evaporated down
  2. customthe residue is purified by chromatography

Sources & evidence

ORD record
ord-a9ffa0ccfa034e5894a2b55c9a494f1b
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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