Trifluoroacetic acid → HCID 24254482, compound

HRID 2110928Notes

Reaction equation

HRID 2110928 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[O:11][C:12]([CH2:15][CH3:16])=[N:13][N:14]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:15]([C:12]1[O:11][C:10]([CH2:9][CH2:8][NH2:7])=[N:14][N:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57636978HCID 57636978, compound

Product 1

HCID 24254482HCID 24254482, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.95 g (12.23 mmol) tert-butyl[2-(5-ethyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 10 ml trifluoroacetic acid are stirred in 100 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

Workup

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-2117e0e32c4f415c80a1edaf976c0ee8
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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