Trifluoroacetic acid → 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

HRID 2110935Notes

Reaction equation

HRID 2110935 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[O:11][C:12]([CH:15]([CH3:17])[CH3:16])=[N:13][N:14]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:15]([C:12]1[O:11][C:10]([CH2:9][CH2:8][NH2:7])=[N:14][N:13]=1)([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57637115Tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate

Product 1

HCID 242544832-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.00 g (15.67 mmol) tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 20 ml trifluoroacetic acid are stirred in 200 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

Workup

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-3cd64995c32240518fbf2960fd30cdf7
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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