Hydrochloric Acid → [2-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

HRID 2110936Notes

Reaction equation

HRID 2110936 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH2:15][CH3:16])[N:11]=1)(C)(C)C.[ClH:18]>ClCCl>[ClH:18].[CH2:15]([C:12]1[N:11]=[C:10]([CH2:9][CH2:8][NH2:7])[O:14][N:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 57637085[2-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 53398851[2-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

2.05 g (8.50 mmol) tert-butyl[2-(3-ethyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 20 ml dichloromethane, 40 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 16 hours at ambient temperature and for 4 hours at 40° C. After the addition of a further 10 ml ethereal hydrochloric acid the mixture is stirred for another 72 hours at ambient temperature. The suspension is evaporated down.

Workup

  1. stirringis stirred for another 72 hours at ambient temperature
  2. customThe suspension is evaporated down

Sources & evidence

ORD record
ord-a2299e9580f148128c8d372d8de2571e
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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