Hydrochloric Acid → 2-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)ethan-1-amine hydrochloride

Participants

Reaction Steps

4.00 g (15.79 mmol) tert-butyl[2-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 40 ml dichloromethane, 80 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 3 hours at reflux temperature and 72 hours at ambient temperature, then evaporated down. The residue is dissolved in acetone, mixed with diethyl ether and suction filtered.

Provenance & Evidence