Hydrochloric Acid → 2-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)ethan-1-amine hydrochloride

HRID 2110940Notes

Reaction equation

HRID 2110940 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH:15]2[CH2:17][CH2:16]2)[N:11]=1)(C)(C)C.[ClH:19]>ClCCl>[ClH:19].[CH:15]1([C:12]2[N:11]=[C:10]([CH2:9][CH2:8][NH2:7])[O:14][N:13]=2)[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57637077Tert-butyl[2-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate

Product 1

HCID 534336432-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)ethan-1-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.00 g (15.79 mmol) tert-butyl[2-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 40 ml dichloromethane, 80 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 3 hours at reflux temperature and 72 hours at ambient temperature, then evaporated down. The residue is dissolved in acetone, mixed with diethyl ether and suction filtered.

Workup

  1. customevaporated down
  2. dissolutionThe residue is dissolved in acetone
  3. additionmixed with diethyl ether and suction
  4. filtrationfiltered

Sources & evidence

ORD record
ord-6d36b4939b054e4f98b594672191d7ea
Source dataset
uspto-grants-2009_04
Patent number
US07517995B2

Reaction notes

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