反应详情

温度

80 °C

Aluminium chloride (2 g) was suspended in 3 ml of fluorobenzene. A solution of 6-chloronicotinoyl chloride (1 g, 5.7 mmol) in 2 ml of fluorobenzene was added to the stirred reaction mixture by syringe and stirred at 80° C. overnight in a closed vial. The reaction mixture was deluted with EtOAc and basified with aqueous sodium hydroxide (pH>8.5). The precipitate formed was removed by filtration. The organic solution was washed with water, dried over magnesium sulfate and concentrated by rotary evaporation. Desired product was purified by column chromatography on silica (EtOAc/hexane) to give 1.22 g (90%).

1. customThe precipitate formed
2. customwas removed by filtration
3. washThe organic solution was washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated by rotary evaporation
6. customDesired product was purified by column chromatography on silica (EtOAc/hexane)
7. customto give 1.22 g (90%)