Water → HCID 57636765, compound

HRID 2110991Notes

Reaction equation

HRID 2110991 reaction equation
[Br:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([N+:15]([O-])=O)=[N:13][CH:14]=2)=[CH:4][CH:3]=1.O>C(O)(=O)C.[Fe]>[Br:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:15])=[N:13][CH:14]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 962WaterHCID 57636801HCID 57636801, compound

Product 1

HCID 57636765HCID 57636765, compoundYield 97.4%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

5-[(6-bromo-3-pyridinyl)oxy]-2-nitropyridine 65 mg, 0.22 mmol) was dissolved in acetic acid (1.5 ml) and water (2 ml) and heated to 50 degrees C. Iron powder (42 mg, 0.75 mmol) was added and the mixture was left for 1 h. Filtration and purification by column chromatography on silica (ethyl acetate/hexane 2:1) gave 57 mg, 97% of desired product.

Workup

  1. filtrationFiltration and purification by column chromatography on silica (ethyl acetate/hexane 2:1)

Sources & evidence

ORD record
ord-b3ecfde3db5942eaaa29bc93b4a18ea5
Source dataset
uspto-grants-2009_04
Patent number
US07517992B2

Reaction notes

Loading…