N-(3-Fluorophenyl)-6-nitropyridin-3-amine → HCID 28477225, compound

HRID 2110992Notes

Reaction equation

HRID 2110992 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:10]=[N:11][C:12]([N+:15]([O-])=O)=[CH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1>[Ni].CO>[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[N:11][CH:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 57636791N-(3-Fluorophenyl)-6-nitropyridin-3-amine

Product 1

HCID 28477225HCID 28477225, compoundYield 98.4%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

This compound was easily prepared from N-(3-fluorophenyl)-6-nitro-3-pyridinamine 210 mg, 0.9 mmol) by catalytic hydrogenation (Raney nickel at atmospheric pressure) in methanol to give the desired product (180 mg, 98%)

Sources & evidence

ORD record
ord-394ad5acd5af44be9d8edd28a851fb3f
Source dataset
uspto-grants-2009_04
Patent number
US07517992B2

Reaction notes

Loading…