反应详情

To a solution of 1-(2-chlorophenyl)ethyl[3-(4-bromomethylphenyl)-isoxazolyl]carbamate (615 mg, 1.41 mmol) in dichloromethane (18 ml) were added triethylamine (855 mg, 8.47 mmol) and methyl 3-mercaptopropionate (445 mg, 4.23 mmol), and the mixture was stirred overnight at room temperature. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to give the title compound (58.5 mg, 0.123 mmol, 8.7%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with saturated aqueous sodium chloride solution
3. dry with materialdried over anhydrous sodium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was purified by silica gel chromatography (hexane:ethyl acetate=2:1)