Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68880480 | HCID 68880480 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68881466 | HCID 68881466 | 98% |
Reaction Steps
To tert-butyl 5-(4-{[(3-methoxy-3-oxopropyl)thio]methyl}phenyl)isoxazole-4-carboxylate (300 mg, 0.80 mmol) was added 4N hydrogen chloride in 1,4-dioxane (10 ml), and the mixture was stirred overnight at 100° C. The solvent was evaporated under reduced pressure to give the title compound (250 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07517996B2 |
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| Source dataset | uspto-grants-2009_04 |
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| ORD ID | ord-c626e3e0db26466e90197e8fc4bb0ad9 |
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| Source note | uspto-grants-2009_04 |
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