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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2111018Generated: November 3, 2026

Hydrochloric Acid → HCID 68881466, compound

https://huagongshe.com/reaction/2111018

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 68880480HCID 68880480—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 68881466HCID 6888146698%

Reaction Conditions

Temperature100 °C

Reaction Steps

To tert-butyl 5-(4-{[(3-methoxy-3-oxopropyl)thio]methyl}phenyl)isoxazole-4-carboxylate (300 mg, 0.80 mmol) was added 4N hydrogen chloride in 1,4-dioxane (10 ml), and the mixture was stirred overnight at 100° C. The solvent was evaporated under reduced pressure to give the title compound (250 mg, 98%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07517996B2
Source datasetuspto-grants-2009_04
ORD IDord-c626e3e0db26466e90197e8fc4bb0ad9
Source noteuspto-grants-2009_04