Hydrochloric Acid → HCID 68881466, compound

HRID 2111018Notes

Reaction equation

HRID 2111018 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][S:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[O:18][N:17]=[CH:16][C:15]=2[C:19]([O:21]C(C)(C)C)=[O:20])=[CH:10][CH:9]=1.Cl>O1CCOCC1>[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][S:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[O:18][N:17]=[CH:16][C:15]=2[C:19]([OH:21])=[O:20])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68880480HCID 68880480, compound

Product 1

HCID 68881466HCID 68881466, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To tert-butyl 5-(4-{[(3-methoxy-3-oxopropyl)thio]methyl}phenyl)isoxazole-4-carboxylate (300 mg, 0.80 mmol) was added 4N hydrogen chloride in 1,4-dioxane (10 ml), and the mixture was stirred overnight at 100° C. The solvent was evaporated under reduced pressure to give the title compound (250 mg, 98%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c626e3e0db26466e90197e8fc4bb0ad9
Source dataset
uspto-grants-2009_04
Patent number
US07517996B2

Reaction notes

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