反应详情

A mixture of 42.575 g (0.50 mole) of cyclopentylamine (Aldrich), 60.072 g (0.60 mole) of methyl methacrylate (Aldrich) and 250 mL of methanol was heated at reflux under an argon atmosphere for 29 hours, then ca 250 mL of solvent was distilled out at atmospheric pressure. The residue was distilled under vacuum (11 mm Hg, bp 114-116 degrees) to give 76.570 g (82%) of (rac)-3-cyclopentylamino-2-methyl-propanoic acid methyl ester.

1. temperaturewas heated
2. temperatureat reflux under an argon atmosphere for 29 hours
3. distillationca 250 mL of solvent was distilled out at atmospheric pressure
4. distillationThe residue was distilled under vacuum (11 mm Hg, bp 114-116 degrees)