反应详情

A mixture of 1.6 g (0.0045 mole) of 3-[butyl-(2-chloro-5-nitro-pyrimidin-4-yl)-amino]-propionic acid tert-butyl ester (IV-44) in 50 mL of ethyl acetate and 0.5 g of 5% palladium on carbon catalyst was stirred under an atmosphere of hydrogen until hydrogen uptake was complete. The mixture was filtered through a pad of Celite, washing the filter pad with dichloromethane. Concentration of the filtrate under reduced pressure gave 1.3 g of 3-[(5-amino-2-chloro-pyrimidin-4-yl)-butyl-amino]-propanoic acid tert-butyl ester (V-44). This material was used directly in the next step without further purification.

1. filtrationThe mixture was filtered through a pad of Celite
2. washwashing the filter pad with dichloromethane