2,6-Dimethylpiperazine → 4-(cis-3,5-Dimethylpiperazinyl)-2,5-difluorobenzaldehyde

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Reaction Steps

To a solution of 2,4,5-trifluorobenzaldehyde (1 eq) in ethyl acetate at room temperature was added 2,6-dimehtylpiperazine (2 eq). After being stirred overnight, the solution was washed with water, aqueous sodium bicarbonate, brine and dried, and purified on silica gel to give 4-(cis-3,5-dimethylpiperazinyl)-2,5-difluorobenzaldehyde.

Provenance & Evidence