2,6-Dimethylpiperazine → 4-(cis-3,5-Dimethylpiperazinyl)-2,5-difluorobenzaldehyde

HRID 2111483Notes

Reaction equation

HRID 2111483 reaction equation
[F:1][C:2]1[CH:9]=[C:8](F)[C:7]([F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:12][CH:13]1[CH2:18][NH:17][CH2:16][CH:15]([CH3:19])[NH:14]1>C(OCC)(=O)C>[CH3:12][C@H:13]1[NH:14][C@@H:15]([CH3:19])[CH2:16][N:17]([C:8]2[C:7]([F:11])=[CH:6][C:3]([CH:4]=[O:5])=[C:2]([F:1])[CH:9]=2)[CH2:18]1

Participants

4

Reactant 2

HCID 660562,6-DimethylpiperazineHCID 5192782,4,5-Trifluorobenzaldehyde

Product 1

HCID 576382704-(cis-3,5-Dimethylpiperazinyl)-2,5-difluorobenzaldehyde

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 2,4,5-trifluorobenzaldehyde (1 eq) in ethyl acetate at room temperature was added 2,6-dimehtylpiperazine (2 eq). After being stirred overnight, the solution was washed with water, aqueous sodium bicarbonate, brine and dried, and purified on silica gel to give 4-(cis-3,5-dimethylpiperazinyl)-2,5-difluorobenzaldehyde.

Workup

  1. washthe solution was washed with water, aqueous sodium bicarbonate, brine
  2. customdried
  3. custompurified on silica gel

Sources & evidence

ORD record
ord-7d3ca4ebab1445feb68254b529598247
Source dataset
uspto-grants-2009_04
Patent number
US07521062B2

Reaction notes

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