反应详情

To a solution of trans-4-aminocyclohexanol (7.90 g., 68.5 mmol) in acetonitrile (150 mL), was added cesium carbonate (51.4 g., 157.5 mmol) and benzyl bromide (18.2 g., 143.8 mmol). The solution was stirred at ambient temperature for 16 hours. The solution was complete by LC-MS and the mixture filtered through a frit, washed with additional acetonitrile, and condensed under reduced pressure. The solid was partitioned between water and dichloromethane (500 mL) and dried over sodium sulfate, filtered and solvent removed under reduced pressure to afford the title compound (17.14 g, 85%). ES-MS (m/z) 296.5 [M+1]+.

1. filtrationthe mixture filtered through a frit
2. washwashed with additional acetonitrile, and condensed under reduced pressure
3. customThe solid was partitioned between water and dichloromethane (500 mL)
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customsolvent removed under reduced pressure