Hydrochloric Acid → 5,6-Indandicarboxylic acid

HRID 2111618Notes

Reaction equation

HRID 2111618 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([C:15]([O:17]CC)=[O:16])=[C:7]([C:10]([O:12]CC)=[O:11])[CH:8]=2)[CH2:3][CH2:2]1.Cl>C(O)(=O)C>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([C:15]([OH:17])=[O:16])=[C:7]([C:10]([OH:12])=[O:11])[CH:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23084541Diethyl 5,6-indandicarboxylate

Product 1

HCID 220353705,6-Indandicarboxylic acidYield 97%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of the product of above-mentioned (a) (0.36 g, 1.4 mmol) in acetic acid (0.8 ml) was added concentrated hydrochloric acid (0.4 ml) and stirred at 80° C. overnight. To the reaction solution was added ice-cold water, and the precipitated crystals were collected by filtration, washed with water, followed by drying to give 0.28 g of 5,6-indandicarboxylic acid.

Workup

  1. additionTo the reaction solution was added ice-cold water
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customby drying

Sources & evidence

ORD record
ord-c43ccb320b3447aa96d8de5d076fe27c
Source dataset
uspto-grants-2009_04
Patent number
US07521451B2

Reaction notes

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