Water → HCID 23084563, compound

HRID 2111626Notes

Reaction equation

HRID 2111626 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[O:8][C:6](=O)[C:5]2=[CH:11][C:12]=1[CH3:13].[NH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1.O>C(O)(=O)C>[CH3:13][C:12]1[CH:11]=[C:5]2[C:4](=[CH:3][C:2]=1[CH3:1])[C:9](=[O:10])[N:14]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[C:6]2=[O:8]

Participants

5

Reactant 3

HCID 962WaterHCID 100093-AminopyridineHCID 2266445,6-Dimethyl-2-benzofuran-1,3-dione

Product 1

HCID 23084563HCID 23084563, compoundYield 82.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4,5-dimethylphthalic anhydride (2.0 g, 11 mmol) and 3-aminopyridine (1.0 g, 11 mmol) were heated under reflux in acetic acid (30 ml) for 1.5 hrs. After standing to cool, water was added thereto, the precipitated crystals were collected by filtration, washed with water, followed by drying to give 2.3 g of 5,6-dimethyl-2-(3-pyridyl)isoindolin-1,3-dione.

Workup

  1. temperatureto cool
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customby drying

Sources & evidence

ORD record
ord-1e1eaff382f64b30aa13f5566ec35aa3
Source dataset
uspto-grants-2009_04
Patent number
US07521451B2

Reaction notes

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