反应详情

Prepared essentially as in 29c except that 4-[1-(3-bromo-5-methyl-thiophen-2-yl)-1-hydroxyimino-methyl]-piperidine-1-carboxylic acid tert-butyl ester is used as the starting material. Two other differences are: 1) 0.05 equivalents of copper iodide is used, and 2) no partition between ethyl acetate and water accompanied by subsequent extraction with ethyl acetate is required. Purification of the residue via flash column chromatography uses a mixture of ethyl acetate: n-heptane (1:4) to yield a white solid. LC/MS (ESI), m/e 345 (MNa+), retention time 2.12 minutes. Condition II.

1. custom2) no partition between ethyl acetate and water
2. extractionaccompanied by subsequent extraction with ethyl acetate
3. customPurification of the residue via flash column chromatography
4. additiona mixture of ethyl acetate: n-heptane (1:4)
5. customto yield a white solid