Hydrochloric Acid → HCID 68574480, compound

HRID 2111924Notes

Reaction equation

HRID 2111924 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][N:5]([CH2:12][C:13]1[O:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[CH:17]=1)[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[ClH:23].C(OCC)C>CO>[ClH:23].[ClH:23].[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][N:5]([CH2:12][C:13]1[O:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[CH:17]=1)[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57640339HCID 57640339, compound

Product 1

HCID 68574480HCID 68574480, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(3-Methylbutyl)-N-[(benzofuran-2-yl)methyl]piperidin-4-amine (0.09 g, 0.28 mmol) is dissolved in methanol (2 ml). 2.0 M HCl in diethyl ether (0.29 ml, 0.57 mmol) is added and the reaction stirred for 2 hours. The reaction is concentrated and the solid dried in a vacuum (60° C.) overnight to yield (0.77 g) of N-(3-methylbutyl)-N-[(benzofuran-2-yl)methyl]piperidin-4-amine dihydrochloride: mass spectrum (ion spray): m/z=301 (M+1).

Workup

  1. concentrationThe reaction is concentrated
  2. customthe solid dried in a vacuum (60° C.) overnight

Sources & evidence

ORD record
ord-019151c10efb4f389a6c33d2e9a29306
Source dataset
uspto-grants-2009_04
Patent number
US07521462B2

Reaction notes

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