Hydrochloric Acid → HCID 68574654, compound

HRID 2111927Notes

Reaction equation

HRID 2111927 reaction equation
[CH3:1][CH:2]([CH3:18])[CH2:3][CH2:4][N:5]([CH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1)[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[ClH:19]>C(#N)C>[ClH:19].[ClH:19].[CH3:1][CH:2]([CH3:18])[CH2:3][CH2:4][N:5]([CH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1)[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57640336HCID 57640336, compound

Product 1

HCID 68574654HCID 68574654, compoundYield 101.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N-(3-methylbutyl)-N-[(1,3-thiazol-2-yl)methyl]piperidin-4-amine (0.13 g, 0.48 mmol) is dissolved in acetonitrile (0.5 ml). 1.0 M HCl (1.93 ml, 1.93 mmol) is added and solution placed under lyophilization conditions to yield (0.166 g) of N-(3-methylbutyl)-N-[(1,3-thiazol-2-yl)methyl]piperidin-4-amine dihydrochloride: mass spectrum (ion spray): m/z=268 (M+1); 1H NMR (DMSO-d6): δ=9.49-9.41 (1H, brd), 9.28-9.19 (1H, brm), 7.94 (2H, dd), 6.42 (1H, brs), 4.77 (2H, s), 3.67-3.56 (1H, brm), 3.38 (2H, d), 3.17-3.09 (2H, brm), 2.94-2.82 (2H, brm), 2.95-2.81 (2H, m), 2.31 (2H, brs), 2.21-2.08 (2H, m), 1.68-1.46 (3H, m), 0.84 (6H, d).

Sources & evidence

ORD record
ord-c27babbf29a3427c8feb8c59074ab123
Source dataset
uspto-grants-2009_04
Patent number
US07521462B2

Reaction notes

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