反应详情

5 g of 2-benzyl-4-chlorophenol, 2.6 ml of chloroacetone, 1.38 g of potassium carbonate and 0.34 g of potassium iodide are dissolved in 50 ml of acetone and boiled under reflux for 20 h. After cooling, the precipitate is filtered, concentrated by evaporation, the residue dissolved in ethyl acetate, the solution washed three times with a 1 n sodium hydroxide solution, then with saturated sodium chloride solution, dried with magnesium sulphate and concentrated by evaporation under vacuum. After recrystallisation from diethylether, 1-(2-benzyl-4-chlorophenoxy)-propan-2-one is obtained as a white powder with a melting point of 65-6° C.

1. temperatureunder reflux for 20 h
2. temperatureAfter cooling
3. filtrationthe precipitate is filtered
4. concentrationconcentrated by evaporation
5. dissolutionthe residue dissolved in ethyl acetate
6. washthe solution washed three times with a 1 n sodium hydroxide solution
7. dry with materialwith saturated sodium chloride solution, dried with magnesium sulphate
8. concentrationconcentrated by evaporation under vacuum
9. customAfter recrystallisation from diethylether