Potassium Iodide → HCID 60626538, compound

HRID 2111956Notes

Reaction equation

HRID 2111956 reaction equation
[CH2:1]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[OH:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:17][C:18](=[O:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[CH2:1]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[O:15][CH2:17][C:18](=[O:20])[CH3:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 8425ChloropheneHCID 11430Potassium Carbonate

Product 1

HCID 60626538HCID 60626538, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5 g of 2-benzyl-4-chlorophenol, 2.6 ml of chloroacetone, 1.38 g of potassium carbonate and 0.34 g of potassium iodide are dissolved in 50 ml of acetone and boiled under reflux for 20 h. After cooling, the precipitate is filtered, concentrated by evaporation, the residue dissolved in ethyl acetate, the solution washed three times with a 1 n sodium hydroxide solution, then with saturated sodium chloride solution, dried with magnesium sulphate and concentrated by evaporation under vacuum. After recrystallisation from diethylether, 1-(2-benzyl-4-chlorophenoxy)-propan-2-one is obtained as a white powder with a melting point of 65-6° C.

Workup

  1. temperatureunder reflux for 20 h
  2. temperatureAfter cooling
  3. filtrationthe precipitate is filtered
  4. concentrationconcentrated by evaporation
  5. dissolutionthe residue dissolved in ethyl acetate
  6. washthe solution washed three times with a 1 n sodium hydroxide solution
  7. dry with materialwith saturated sodium chloride solution, dried with magnesium sulphate
  8. concentrationconcentrated by evaporation under vacuum
  9. customAfter recrystallisation from diethylether

Sources & evidence

ORD record
ord-cef4b59b0bf043e89cdb88c77594afe5
Source dataset
uspto-grants-2009_04
Patent number
US07521476B2

Reaction notes

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