HCID 178487895, compound → 2-[2-(4-amino-3-methoxy-phenyl)-1H-imidazol-4-yl]-ethanol

HRID 2112102Notes

Reaction equation

HRID 2112102 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][CH2:18][OH:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CO.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][CH2:18][OH:19])[N:16]=2)=[CH:4][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 1

HCID 178487895HCID 178487895, compound

Product 1

HCID 1784878942-[2-(4-amino-3-methoxy-phenyl)-1H-imidazol-4-yl]-ethanol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 887MethanolSolvent

Procedure

0.144 g (0.547 mmol) 2-[2-(3-methoxy-4-nitro-phenyl)-1H-imidazol-4-yl]-ethanol are dissolved in 100 ml of methanol and combined with 0.08 g (5%) palladium on charcoal. The reaction mixture is hydrogenated for 16 h at 20° C. and 4 bar H2 pressure. The palladium on charcoal is suction filtered and the methanol is eliminated in vacuo.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-2ff643f36d0e4b78b674535d5239491f
Source dataset
uspto-grants-2009_04
Patent number
US07521457B2

Reaction notes

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