L-Aspartic Acid → Calcium (2S)-2-aminobutanedioate--hydrogen chloride (1/1/1)

HRID 2112352Notes

Reaction equation

HRID 2112352 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[OH-].[Ca+2:11].[OH-].O.O.[Cl-:15].[Ca+2].[Cl-]>O>[ClH:15].[NH2:1][C@H:2]([C:7]([O-:9])=[O:8])[CH2:3][C:4]([O-:6])=[O:5].[Ca+2:11]

Participants

5

Reactant 3

HCID 5960L-Aspartic AcidHCID 6093208Calcium HydroxideHCID 6093260Calcium chloride, dihydrate

Product 1

HCID 71313509Calcium (2S)-2-aminobutanedioate--hydrogen chloride (1/1/1)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1010 l of demineralized water are heated to 60° C., after which 509 kg of L-aspartic acid are added while stirring. 142 kg of calcium hydroxide are added in the form of a powder in portions to the resulting dispersion while stirring continuously. The temperature rises further and the solution becomes clear after about 1 h. A solution of 281 kg of calcium chloride dihydrate in 325 l of water (35% strength solution) is added to this solution. The concentration based on the complex is adjusted to 30% with water. This is followed by filtration and spray drying in the manner described in Example 1.

Workup

  1. stirringwhile stirring continuously
  2. concentrationThe concentration
  3. filtrationThis is followed by filtration and spray
  4. customdrying in the manner

Sources & evidence

ORD record
ord-45f289a565bd40108c1eb60c8ac0b279
Source dataset
uspto-grants-2009_04
Patent number
US07523563B2

Reaction notes

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