HCID 86608934, compound → HCID 86608933, compound

HRID 2112411Notes

Reaction equation

HRID 2112411 reaction equation
I[C:2]1[C:11]2=[CH:12][N:13]([C@@H:15]3[O:21][C@H:20]([CH2:22][OH:23])[C@@H:18]([OH:19])[C@@:16]3([CH3:24])[OH:17])[N:14]=[C:9]3[C:10]2=[C:4]([C:5](=[O:25])[NH:6][N:7]=[CH:8]3)[CH:3]=1.[C:26]([Cu])#[N:27]>CN(C=O)C>[C:26]([C:2]1[C:11]2=[CH:12][N:13]([C@@H:15]3[O:21][C@H:20]([CH2:22][OH:23])[C@@H:18]([OH:19])[C@@:16]3([CH3:24])[OH:17])[N:14]=[C:9]3[C:10]2=[C:4]([C:5](=[O:25])[NH:6][N:7]=[CH:8]3)[CH:3]=1)#[N:27]

Participants

4

Reactant 2

HCID 86608934HCID 86608934, compoundHCID 178418546HCID 178418546, compound

Product 1

HCID 86608933HCID 86608933, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of the title product from Example 19 in DMF is added CuCN/Bu4NCN and the mixture is stirred at 65° C. overnight to form the title compound.

Sources & evidence

ORD record
ord-9b7f4697fba24bde80726d60191d5f8f
Source dataset
uspto-grants-2009_04
Patent number
US07524825B2

Reaction notes

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