HCID 86608936, compound → HCID 86608935, compound

HRID 2112412Notes

Reaction equation

HRID 2112412 reaction equation
[NH2:1][C:2]1[C:11]2=[CH:12][N:13]([C@@H:15]3[O:21][C@H:20]([CH2:22][OH:23])[C@@H:18]([OH:19])[C@@:16]3(C)[OH:17])[N:14]=[C:9]3[C:10]2=[C:4]([C:5](=[O:25])[NH:6][N:7]=[CH:8]3)[CH:3]=1>C(Cl)(=O)C>[NH2:1][C:2]1[C:11]2=[CH:12][N:13]([C@@H:15]3[O:21][C@H:20]([CH2:22][O:23][C:5](=[O:25])[CH3:4])[C@@H:18]([O:19][C:18](=[O:19])[CH2:20][CH3:22])[C@H:16]3[O:17][C:16](=[O:17])[CH3:15])[N:14]=[C:9]3[C:10]2=[C:4]([C:5](=[O:25])[NH:6][N:7]=[CH:8]3)[CH:3]=1

Participants

3

Reactant 1

HCID 86608936HCID 86608936, compound

Product 1

HCID 86608935HCID 86608935, compound

Reagents, catalysts & solvents 1

HCID 6367Acetyl chlorideSolvent

Procedure

To a mixture of the product from Example 14 (100 mg, 0.28 mmol) in acetyl chloride/glacial acetic acid (3 mL, 1:2, v/v) is stirred at room temperature until disappearance of the starting nucleoside, as judged by TLC. The mixture is evaporated in vacuo to dryness and purified on silica gel column.

Workup

  1. customThe mixture is evaporated in vacuo to dryness
  2. custompurified on silica gel column

Sources & evidence

ORD record
ord-ca3568e4e2ed4700afc4111cc807dfbf
Source dataset
uspto-grants-2009_04
Patent number
US07524825B2

Reaction notes

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