HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine → 4-(3-Methyl-1-piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Reactant | 4-Bromo-1-(2-methyl-benzenesulfonyl)-1H-indole | HCID 22015334 | — |
| Product | 4-(3-Methyl-1-piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole | HCID 22015381 | 38% |
Reaction Steps
The compound was prepared from 4-bromo-1-(2-methyl-benzenesulfonyl)-1H-indole and 3-methylpiperazine according to Method 1 to give 110 mg (38%) of a white solid: 1HNMR (CD3OD) δ 7.92-6.82 (m, 9H), 3.64-3.39 (m, 5H), 3.12-3.03 (m, 1H), 2.92-2.83 (m, 1H), 2.47 (s, 3H), 1.40 (d, J=7 Hz, 3H); MS (ESI) 370.0 (M+H)+; Purity (HPLC) 94%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524839B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-61f74b85fc4641d38ac1b2213e279522 |
| Source note | uspto-grants-2009_04 |