2-Chlorobenzaldehyde → (2-Amino-5-methoxy-4-trifluoromethylphenyl)-(2-chlorophenyl)-methanone

HRID 2112478Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:10][O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][C:13]=1[C:19]([F:22])([F:21])[F:20]>>[NH2:16][C:15]1[CH:14]=[C:13]([C:19]([F:21])([F:22])[F:20])[C:12]([O:11][CH3:10])=[CH:18][C:17]=1[C:4]([C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[Cl:1])=[O:5]

Participants

Reactant 2

HCID 69962-Chlorobenzaldehyde

HCID 6007055-Amino-2-methoxybenzotrifluoride

Product 1

HCID 57642380(2-Amino-5-methoxy-4-trifluoromethylphenyl)-(2-chlorophenyl)-methanone

Procedure

(2-amino-5-methoxy-4-trifluoromethylphenyl)-(2-chlorophenyl)-methanone (Xee) was prepared by reacting 2-chlorobenzaldehyde with 0.0263 moles of 4-methoxy-3-trifluoromethyl aniline in a manner analogous to Example 1. MH+/Z=330.

Sources & evidence

ORD record: ord-32ad550b046a4324b8dd145941c138f0
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524840B2

Reaction notes

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